Masks and Covid-19

Noon 24-MarchCasesDeathsParishes
St. Mary Parish20
Louisiana1,3884643 of 64
United States45,786544
World407,48518,227
Italy69,1766,820

MASKS

As the Covid-19 outbreak grows exponentially across the globe and particularly in the United States, there has been a run on medical masks of all types. This has created an acute shortage of masks for those in most in need of them, the doctors, nurses and emergency response personnel on the front line of the fight against this growing killer. All the while, masks which would be a big help in hospital settings are being used by average citizens who falsely believe they provide them with an adequate level of protection.
To discuss masks, we must first look at the three major types of masks available: respirators, manufactured surgical masks, and mostly homemade cloth masks. All of these have their place and uses, as we will see. However, those uses may not be applicable to the Covid-19 outbreak and SARS CoV 2 virus which causes it.

RESPIRATORS

Respirators are tightly fitting masks specifically designed to filter out the overwhelming majority of airborne particles. The most common respirator one will come across today is the N95 respirator. They are tight-fitting masks that filter out at least 95% of small and large airborne particles, according to the CDC. They are recommended for use by health care workers in the treatment of the coronavirus. However, even when properly fitted, an N95 mask “does not completely eliminate the risk of illness or death,” according to the Us Food and Drug Administration.

The N95 respirator is designed to filter out 95% of particles which are 300 nanometers (nm) in size or larger. This makes them effective against most airborne pathogens but not all. In fact, they are slightly less efficient against SARS CoV 2 as the average size of viral particles is only 100 nm. Thus a single SARS CoV 2 virus could race right through an N95 respirator.

Thankfully, the infected human body puts out thousands of these particles, many of them attach to mucous or water molecules in coughs and sneezes. The latter virus particles, attached to say mucous or even a water molecules, are much then too big to pass through N95 pores.

While free floating virus particles may be smaller than the pores of the mask, thankfully there are so many of them that they clog pores when more than two try to enter. Think of this analogy: one teenage boy can easily fit through a standard doorway, but if three of them try to get through at the same time, it just does not work. So, in this case, we use the massive reproduction of the SARS CoV 2 against itself.

All that said, it is not a complete solution. By their very nature, N95 respirators only block 95% of those particles 300 nm and larger. On average 5% get through. The small size of SARS CoV 2 likely bumps that percentage up even more. This also assumes the respirator is properly fitted and applied. This is not always that easy.

“Achieving an adequate seal to the face is essential,” according to the CDC. “United States regulations require that workers undergo an annual fit test and conduct a user seal check each time the respirator is used. Workers must pass a fit test to confirm a proper seal before using a respirator in the workplace. When properly fitted and worn, minimal leakage occurs around edges of the respirator when the user inhales.” This makes N95 respirators very uncomfortable to wear and dangerous for those with various health conditions, including those who are pregnant, due to the reduction in air flow. Nor can they be effectively used by those with facial hair.

N95 respirators are also supposed to be single use masks for health care workers, but with the acute shortage of this vital protective device worldwide, many health care workers are being asked to save their N95s and reuse them. This also decreases efficiency. In addition, it becomes more difficult to assure good face seals with repeated use. Finally, the continued use of N95 respirators by health care workers can cause skin breakdown along the seal area from the constant pressure of the mask.

CDC Graphics compares N95 respirators and Surgical Masks

SURGICAL MASKS

“A surgical mask is a loose-fitting, disposable device that creates a physical barrier between the mouth and nose of the wearer and potential contaminants in the immediate environment,” according to the CDC. “Surgical masks are regulated under 21 CFR 878.4040. Surgical masks are not to be shared and may be labeled as surgical, isolation, dental, or medical procedure masks. They may come with or without a face shield. These are often referred to as face masks, although not all face masks are regulated as surgical masks.”

These are the masks used by dentists, doctors and nurses in normal daily activities. They are also the same as most such masks sold at drug stores and such. Some face masks may not be designed to the statute noted above and thus are not labeled as “surgical masks.” However, for our purposes, we will treat all these the same as their protective qualities are quite similar.

Where an N95 respirator can stop particles down to 300 nm in size, surgical masks are designed to stop particles down to 5000 nm in size. We go from three virus particle-width pores to 50 particle-width pores. This size of opening is not even completely effective against larger, virus laden, mucous particles in coughs and sneezes. This is because surgical masks are not designed to stop such small particles.

“If worn properly, a surgical mask is meant to help block large-particle droplets, splashes, sprays, or splatter that may contain germs (viruses and bacteria), keeping it from reaching your mouth and nose,” according to the CDC. “Surgical masks may also help reduce exposure of your saliva and respiratory secretions to others.”

They are designed to protect the health care workers from fluids that may be splashed or projected towards them in procedures. They also help prevent coughs or sneezes from transmitting as many particles from the health care worker reaching the patient. They are not designed to protect the health care worker from whatever disease the patient has. That job goes to the N95 respirators.

Finally, surgical masks are not fit to the person’s face. By their very design, they allow air flow around the mask. Thus, virus laden air flow can just travel right around the sides and infect the wearer. This makes them very ineffective against Covid-19.

CLOTH MASKS

The last form of masks are cloth masks being sewn across the country by those trying to help health care workers face growing shortages. For the most part, anything written about surgical masks applies to cloth masks as well. They are not adequate replacements for N95 respirators, nor truly as effective as surgical masks. A study published in The Annals of Occupational Hygiene showed that up to 70% of infective particles were able to penetrate average cloth masks. It must also be remembered that efficacy is based upon the type of cloth used, the number of layers and other factors. In general, though, hand-sewn cloth masks should not be considered as effective as surgical masks and are nowhere near the effective nature of N95 respirators.

That said, the sewing of such masks for use by health care workers is highly encouraged. Any protection is better than no protection at all, which is what many health care workers will soon be facing. These efforts are admirable and health care workers across the country are applauding the assistance.

CONCLUSION

The only masks which offer any true protection against the SARS CoV 2 virus are N95 respirators. The CDC does not recommend the use of N95 respirators outside of hospitals and other medical workplace settings. This scarce resource is essential to protecting health care workers on the front lone of the Covid-19 outbreak. Using them anywhere else puts a health care worker in danger and potentially reduces the health care workforce which you may need if or when you get Covid-19.

“Most often, spread of respiratory viruses from person-to-person happens among close contacts (within 6 feet),” notes the CDC. Rather, all of us should use everyday preventive actions to prevent the spread of Covid-19, such as avoiding people who are sick, avoiding touching your eyes or nose, and covering your cough or sneeze with a tissue or your elbow. People who are sick should stay home and not go into crowded public places or visit people in hospitals.

Simply washing your hands as often as possible and social distancing are far more effective means of preventing the spread of, or acquiring, Covid-19 than any use of face masks, even N95 respirators.

What is it Like to Have Covid-19?

10 AM 22-MarCasesDeathsParishes
St Mary Parish10
Louisiana8372036
United States30,491390
World328,27514,366
Italy46,6385,476

UPDATE: AT 2 PM GOVERNOR EDWARDS ANNOUNCED A STAY HOME AND SHELTER IN PLACE ORDER FOR THE ENTIRE STATE BEGINNING AT 5 PM MONDAY, MARCH 23, IN AN EFFORT TO SLOW THE NUMBER OF COVID-19 CASES IN LOUISIANA. WE NOW LEAD THE WORLD IN THE GROWTH OF CASES. THIS IS NOT A TIME WE WANT TO BE NUMBER 1!!

I have concentrated in past on the virus itself and how it is spreading. Today I will look at the course of the disease itself. Before I start describing the evolution of the disease process, it needs to be understood that not everyone has the severe course we will discuss. In fact, as previously noted, some will not even know they have anything other than a mild cold or allergies. That said, no matter how dangerous the severity of the course of the disease, the person infected can spread the disease to anyone they come in contact with.

Most of those infected will either have been within 6-9 feet of someone infected or come in contact with virus particles on a surface. The virus particles make their way to the nose, mouth, and/or nose of the victim and are further transferred into the body and lungs via respiration and swallowing. Once in the body, the virus seeks out cells with ACE2 receptors. Then like a lock and key, the spike protein on the SARS CoV 2 virus attaches perfectly with an ACE2 receptor, allowing the strand of RNA in the virus to hijack the cell and begin reproducing more virus particles.

By the third day post contact, the virus is reproducing in such quantities that the body begins to shed thousands of virus particles with each breath. It is likely that saliva, tears, and possibly other bodily secretions also contain the virus. As the virus spreads throughout the body, the immune system senses an invasion by an outside organism and begins to mount an immune response. The myriad of antibodies in our body begin to see which ones might be able to attack the virus. Once antibodies begin to attach to the virus particles, the body begins to produce more of those specific antibodies. Within a few days, these antibodies can be detected in the body.

As the body cranks up its immune response, we begin to see the body try and fight off the virus. This is Day 1 of the illness. The body acts by raising the its temperature, fever, and trying to get rid of the invader by coughing. So the early symptoms are a dry cough, fever, headache, body aches, and fatigue, similar to when you have the seasonal flu. In about 80 % of cases, symptoms will get only slightly worse than the seasonal flu.

But in those cases involving elderly patients and those with other aggravating illnesses and compromised immune systems, things continue to worsen. Those 20% or so remaining victims will likely require hospitalization for their symptoms and distress. This normally occurs on about Day 7. The lungs are the primary target of the Covid-19 virus and as the virus works down the respiratory tract, we see the symptoms to evolve into case similar to bronchitis and eventually pneumonia.

Our lungs are made up of tiny air sacs known as alveoli. As the immune response battle moves to the lungs, the dry cough becomes a moist one. The alveoli come under attack by the virus and the virus is attacked by the immune system. This leads to an increase in secretions in the lungs and a thickening or swelling of the lining of the alveolar sacs, all of which leads to a build up of secretions in sections of the lungs, which causes a decrease in the capacity to process oxygen. Shortness of breath and a wet cough enter the symptom mix.

With less oxygen entering the system, organs such as the liver, kidneys and brain begin to work less efficiently and even fail. As more fluids build up in the lungs, consolidation, the blocking of entire sections of the lung by secretions, leads to expanding pneumonia. Things happen quicker now and by Day 8 a small percentage, about 5-7%, will develop acute respiratory distress syndrome (ARDS). They require intensive care and ventilator support to deliver more oxygen to the body.

Should the lungs be damaged too much, we see organ failure and death. This is the end game for those faced with serious ARDS cases of the Covid-19 virus. Unlike cases of pneumonia caused by bacteria, there are no antibiotics which can fight the Covid-19 virus. Antibiotics may be used to prevent bacterial pneumonia from forming as well but will have no impact on the virus itself. By Day 11 or 12, those with serious ARDS will normally succumb to the illness.

Those who survive past day 12 and go on to survive the illness will normally be feeling better by Day 17 and those hospitalized in the ICU are normally released after a little over two weeks. They will now have a natural immunity to the virus. We do not know how long this immunity lasts, but history tells us we should be good for a year or so, Hopefully long enough to see a vaccine enter the picture.

As always, Stay Home, and Stay Safe. Follow the instructions of federal, state and local officials. It will save lives!

St Mary Reports First Covid-19 Case

In its 5:30 PM update, the Louisiana Department of Public Health added St Mary Parish to the growing list of parishes with confirmed Covid-19 cases. There are now 763 cases in 35 parishes and 16 dead in Louisiana. More in tomorrow’s blog.

Stay Safe!

Looking at SARS CoV-2

Data as of 10 AM 21-March:

Covid 19 CasesCasesDeathsParishes
Louisiana5851629
St. Mary
World286,81611,837
United States19,775276
Italy47,0214,032

Today we will take at look at the SARS CoV 2 virus which is the causative agent of the Covid-19 outbreak. As scientists have more time to study the virus, since it has moved outside of China, information on it is growing.

First off, lets address the conspiracy theorists out there who claim the SARS CoV 2 virus is a product of Chinese or other military labs. Information released yesterday by the Scripps Research Institute shows the virus is of natural origin.

“By comparing the available genome sequence data for known coronavirus strains, we can firmly determine that SARS-CoV-2 originated through natural processes,” said Kristian Andersen, PhD, associate professor of immunology and microbiology at Scripps, and lead author on the paper, “The proximal origin of SARS-CoV-2,” . Anderson, along with coauthors Robert F. Garry, Tulane University; Edward Holmes, University of Sydney; Andrew Rambaut, University of Edinburgh; and W. Ian Lipkin, Columbia University say SARS CoV 2 show no evidence of being created in a laboratory or engineered in any form.

This is a computer generated image of the spike protein that acts as the key to unlock the human ACE2 receptor found on many human pulmonary cells. Courtesy: Cell Magazine

Evidence shows the SARS CoV 2 virus is a mingling in many ways of the SARS CoV virus and the MERS virus. The strongest evidence of natural evolution came from the receptor-binding domain of the SARS CoV 2 virus, which has evolved over time to very selectively bind to the human ACE2 receptor, found on many human cells including those in the respiratory system. The receptor-binding domain is also known as the SARS CoV 2 “spike protein.” The virus binds so well that scientists say it could only be the result of “natural selection.”

As to SARS CoV 2 itself, we are finally seeing some actual photos of the virus. All of the following come from electron microscope imagery:

Image of a single SARS CoV 2 virus from the Smorodintsev Research Institute of Influenza in Russia. Note the bar on the bottom which is equal to 200 nano meters (nm). For reference, there are 1 billion nano meters in one meter.
Transmission electron microscope image of SARS CoV 2 viruses, with their spike proteins, exiting a cell which the virus hijacked to reproduce itself. Courtesy: NIAID-RML
A group of SARS CoV 2 viruses, yellow, cluster on growth medium in this electron microscopic image. Courtesy: NIAID-RML

Thus, SARS-CoV-2 virus belongs to the genera of Beta Coronaviruses, in the order of Nidovirales, family of Coronaviridae and sub-family of Orthocoronavirinae. It is round or elliptical with a diameter of approximately 100 nm.

Here is an amazing graphic of the structure of the SARS CoV 2 virus from a recent article in the Economist.

As we can see, the virus is a very simple design. It is composed of a lipid membrane capsule, which surrounds a nucleocapsid protein that contains the RNA sequence of about 30,000 base pairs. On the outside of the capsule are the spike proteins, which so easily bind to the ACE2 receptors of human cells, especially those in the respiratory system.

It is amazing that something so small, so simple, and non-living, has in a matter of weeks brought the world to its knees. Yet, we are only in the infancy of this outbreak. How long it lasts, and we need to hope it is stretched out over months, and how severe the implications, lay with how well we as citizens can abide by the restrictions put in place.

The future of the outbreak, specifically how bad it gets, is in all of our hands. Hopefully, we have the resolve to recognize the common good above personal need and want and do what is asked. Because barring a vaccine, likely at least a year away, social distancing and isolation is the only answer.

Stay safe and follow the orders of federal, state and local health officials.

How Much Damage can One Person Do?

Here is the data update for Thursday, 19-March.

LocationCasesDeaths Parishes
Louisiana347817
United States9514141
World222,6429,106
Italy31,5062,978
St Mary Parish00

Today we will take a look at South Korea and the story of the now infamous “Patient 31.” As a relatively small country, both in land mass and population, South Korea has led the world in limiting the effects of the Covid-19 outbreak. They did this through a huge testing campaign, tracking of all of those who had been in contact with anyone known to be infected, and strong self-isolation policies to prevent spread. It is the tracking of how many people each infected person came in contact with, which provides the answer to the question posed above: “How much damage can one person do?”

The first eleven cases in South Korea were traced back to having come in contact with between two and one hundred people. A lot of exposure and many of those contacted became future cases but nothing out of the ordinary. Then came Patients 12 and 14, a married couple who came in contact with 425 people. The first major community spread. Patient 16 would be in contact with 450 people themselves, becoming the largest spreader of the disease to that point. Patients 17-30 would only be in contact with between 10 and 40 people each before they were isolated.

Then came Patient 31, a 61-year-old woman, who was to become the focus of her own major outbreak. It is not known when the woman was infected. However, we do know that on 2-Jan, she visited the C-Club in Seoul, South Korea, a club purportedly tied to the Shincheonji church. Seoul, a city of just under 10 million is in the northern part of the country. The Shincheonji Church of Jesus is a secretive sect that believes the churches founder Lee Man-hee is the returned Jesus Christ and Lee is the only person who can interpret the secret metaphors of the Bible. It has over 300,00 followers in South Korea.

On 6-Feb, Patient 31 was involved in a motor vehicle accident in the southern city of Daegu after visiting a C-Club there. Daegu is a city of 2.5 million in the North Gyeongsang Province. On 7-Feb, Patient 31 was hospitalized in Saeronan Oriental Medicine Hospital in Daegu. The following day, she traveled home and collected personal belongings before returning to the hospital.

On 9-Feb, Patient 31 left Saeronan Hospital of her own accord and attended two hours of services at Shincheonji Church of Jesus in Daegu, before returning to the hospital. She began running a fever on 10-Feb. On 15-Feb, doctors strongly suggested that she be tested for the SAR CoV-2 virus. She refused, instead taking a taxi from the hospital to the Queen Vell Hotel, where she had lunch with a friend or friends then took at taxi back to the hospital. The next day, she was again advised to be tested for the coronavirus but refused and again traveled from the hospital to two hours of services at Shincheonji Church of Jesus in Daegu. On leaving the services, she traveled to a local clinic where she was tested for SAR CoV-2, before returning to the hospital. At this point, she transferred to Daegu Medical Center where on 17-Feb she was notified she had tested positive, becoming Patient 31 in Korea.

In her wandering travels, Patient 31 came in contact with a known 1,160 persons and untold others. She brought the disease to two hospitals and a clinic, as well as Shincheonji Church of Jesus in Daegu. In the following days, Daegu and the Shincheonji Church of Jesus there would become the nexus for the spread of Covid-19 in South Korea

Courtesy Reuters

The map above shows the impact one person had on the outbreak in South Korea. Daegu is the large blue circle in southern Korea. Seoul with five times the population is one of the small circles in the north. One person can clearly make a difference and have a huge impact on outbreaks. Patient 31 surely did!

Stay safe. Self-isolate and follow the directives of state, local and federal officials.